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Although the doses in studies were only 1-3mg daily, bodybuilders use ostarine at 10-25mg with a PCT being recommended due to the testosterone suppression that follows after a cycle.
The dosage does get quite high though. One study showed that a cycle of ostarine with a dose of 50mg daily for 1-4 days (for an initial dosage of 3g) resulted in a testosterone spike of more than 25% within 90min! Ostarine is now known to also work on the adrenal glands.
The one exception to this is one compound called cyproterone-A, which is often used on high-end bodybuilding drugs but, like ostarine, this compound also promotes testosterone production.
What does it do?
Ostarine is used to increase bioavailability of steroids in a compound known by the scientific-sounding acronym, TRPV3 (Thyroid Receptor Stimulating hormone 1).
TRPV3 is a protein in the endoplasmic reticulum which is important for uptake and metabolism of steroids.
When you reduce TRPV3 through diet, you reduce the uptake of steroids. In addition to increased absorption, Trenbolone use also results in a reduction of the bioavailability of testosterone due to the decreased bioavailability of the steroid due to TRPV1 and TRPV3 downregulation. The testosterone used on steroids also acts on receptors in the testicle gland leading to increased expression of the growth hormone receptors which are then increased during the cycle when testosterone is used.
For example, when a bodybuilder cycles 20 cycles with oral Trenbolone (400mg orally, 1oz. bodyweight) they are increasing their testosterone levels by 4-5x! This is called an “effectively testosteroneic cyclic dose.”
TRPV3 regulates steroid hormone receptor expression in the testicle. It also stimulates the aromatase enzyme that converts testosterone to estrogen which in turn stimulates the release of estrogen to the hypothalamus.
What does it do to women’s breasts and what does it do to ovaries?
Ostarine, through its role in increasing bioavailability of Trenbolone has been found to increase estrogen levels in breast tissue causing hormone levels to rise in the same manner as testosterone by directly affecting TRPV3.
However, women have their own way of experiencing these actions, as well as the effects they have.
Although an estradiol increase occurs in breast tissue, breast tissue also has low levels of oestrogen. As such, an estradiol increase might be expected to have an opposite effect.
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