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Boldenone’s level of estrogenicity is less clear as there is no solid data available that provides details on its interaction with aromatase in humans. William Llewellyn stated in in his book Anabolics that Boldenone is a less potent substrate for aromatase and is enzymatically metabolized into Estrogen at 50% of the rate of Testosterone, natural ketogenic bodybuilding. This claim is not supported in any of the clinical data I have personally seen, so I would be hesitant to assume that Boldenone can facilitate sufficient Estrogen receptor activation in practical application as the base of a cycle. There is also speculation around whether or not certain Boldenone metabolites act as aromatase inhibitors and attenuate the estrogenic activity of the parent hormone. While this is certainly possible and warrants further research before we can make any conclusive statements about Boldenone, in general with our knowledge to date it is fairly well accepted in the community that Boldenone is mildly estrogenic, but significantly less so than Testosterone and Dianabol.
The protein size decrease is almost entirely a result of the loss of homopolymeric amino acid repeats, suggesting that these repeats, which are found in many developmental regulatory proteins, are not integrally involved in E75 function, natural ketogenic bodybuilding.
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