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Some receptors in the plasma membrane physically interact with heterotrimeric G-proteins that reside on cytoplasmic surface of the plasma membrane, somagen careers. Heterotrimeric G-proteins consist of an alpha subunit (Gα) that binds and hydrolyzes GTP and a beta and a gamma subunits (Gβγ) that inhibit Gα but can also participate in signaling reactions. The receptors are notable because they span the membrane 7 times and contain a guanine nucleotide exchange (GEF) domain.
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